Stim-HSN™

Move beyond biotin and discover the beauty potential of polyamines. STIM-HSN® Polyamine Extract, developed by Oryza Oil & Fat Chemical Co., Ltd. of Japan, delivers naturally occurring spermidine, spermine, and putrescine derived from nutrient-dense rice germ. These essential cellular compounds are present throughout the body and play important roles in cell proliferation, renewal, keratin production, and healthy aging. Polyamine levels naturally decline with age, making supplementation an increasingly attractive strategy for supporting healthy hair, skin, and nails from within.

The hair-growth story behind STIM-HSN® is particularly compelling. Published research on spermidine has demonstrated the ability to prolong the hair follicle anagen (growth) phase, while Oryza’s own research showed rice-derived polyamines increased dermal papilla cell proliferation by 40-60% and upregulated key hair-growth signaling factors including HGF, FGF-7, VEGF, and IGF-1. Together, these findings suggest support for thicker, healthier-looking hair through natural cellular renewal pathways.

Beyond hair health, STIM-HSN® offers a broader beauty-from-within platform. Oryza studies demonstrated support for nail appearance, ceramide content, moisture retention, hair cuticle integrity, and anti-glycation activity associated with collagen matrix preservation. Combining beauty, healthy aging, and cellular renewal into a single ingredient story, STIM-HSN® should be a go-to ingredient for formulators developing next-generation hair, skin, nail, beauty, longevity, and healthy aging products.